Tirzepatide is the first GIP/GLP1 receptor co-agonist used in clinical practice. It retains 9 homologous amino acids of GIP and 10 amino acids shared by GIP and GLP-1.
Tirzepatide is effective in weight loss and is superior to single use of GLP-1 agonists such as Semaglutide.
Tirzepatide has become a potential drug for the treatment of metabolic diseases due to its innovative dual-target mechanism and significant efficacy.
It works in the following ways:
(1) Enhances glucose-dependent insulin secretion and inhibits glucagon release.
(2) Increases satiety and regulates appetite.
(3) GIP works synergistically with GLP-1 to reduce calorie intake.
| Tests | Specifications | Results |
| Appearance | White powder | Conforms |
| Solubility | Soluble in water | Conforms |
| Purity(HPLC) | ≥98.0% | 99.11% |
| Related Substance(HPLC) | Any individual impurity≤1.0% | 0.37% |
| Amino Acid analysis | Asp 1.6~2.4 | 2 |
| Tyr 1.6~2.4 | 2 | |
| Lys 1.6~2.4 | 2.1 | |
| Ile 2.0~3.2 | 2 | |
| Leu 1.6~2.4 | 2 | |
| Val 0.8~1.2 | 1 | |
| Thr 1.6~2.4 | 2 | |
| Phe 1.6~2.4 | 2 | |
| Ser 4.0~6.0 | 4.5 | |
| Ala 3.2~4.8 | 4 | |
| Gly 3.2~4.8 | 4 | |
| Glu 3.2~4.8 | 4.3 | |
| Pro 3.2-4.8 | 3.4 | |
| Aib N/A | / | |
| AEEA N/A | / | |
| Sodium salt | <5.0% | 0.83% |
| Peptide Content | ≥85.0% | 92.31% |
| Water Content (Karl Fischer) | ≤10.0% | 3.56% |
| Residual solvents | Acetonitrile NMT 410ppm | Conforms |
| Methanol NMT 3000ppm | Conforms | |
| Bacterial endotoxin | <10EU/mg | Conforms |
| Microbial Limits | Total aerobic microbial count ≤1000cfu/g | Conforms |
| Total yeast and mold count ≤200cfu/g | Conforms | |
| MS (ESI) | 4813.45±1.0 | 4813.19 |
| Assay(HPLC) | 95.0~105.0%(on anhydrous and salt-free substance basis) | 100.10% |
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