Tirzepatide is the first GIP/GLP1 receptor co-agonist used in clinical practice. It retains 9 homologous amino acids of GIP and 10 amino acids shared by GIP and GLP-1.
Tirzepatide is effective in weight loss and is superior to single use of GLP-1 agonists such as Semaglutide.
Tirzepatide has become a potential drug for the treatment of metabolic diseases due to its innovative dual-target mechanism and significant efficacy.
It works in the following ways:
(1) Enhances glucose-dependent insulin secretion and inhibits glucagon release.
(2) Increases satiety and regulates appetite.
(3) GIP works synergistically with GLP-1 to reduce calorie intake.
| Tests | Specifications | Results |
| Appearance | White powder | Conforms |
| Solubility | Soluble in water | Conforms |
| Purity(HPLC) | ≥98.0% | 99.11% |
| Related Substance(HPLC) | Any individual impurity≤1.0% | 0.37% |
| Amino Acid analysis | Asp 1.6~2.4 | 2 |
| Tyr 1.6~2.4 | 2 | |
| Lys 1.6~2.4 | 2.1 | |
| Ile 2.0~3.2 | 2 | |
| Leu 1.6~2.4 | 2 | |
| Val 0.8~1.2 | 1 | |
| Thr 1.6~2.4 | 2 | |
| Phe 1.6~2.4 | 2 | |
| Ser 4.0~6.0 | 4.5 | |
| Ala 3.2~4.8 | 4 | |
| Gly 3.2~4.8 | 4 | |
| Glu 3.2~4.8 | 4.3 | |
| Pro 3.2-4.8 | 3.4 | |
| Aib N/A | / | |
| AEEA N/A | / | |
| Sodium salt | <5.0% | 0.83% |
| Peptide Content | ≥85.0% | 92.31% |
| Water Content (Karl Fischer) | ≤10.0% | 3.56% |
| Residual solvents | Acetonitrile NMT 410ppm | Conforms |
| Methanol NMT 3000ppm | Conforms | |
| Bacterial endotoxin | <10EU/mg | Conforms |
| Microbial Limits | Total aerobic microbial count ≤1000cfu/g | Conforms |
| Total yeast and mold count ≤200cfu/g | Conforms | |
| MS (ESI) | 4813.45±1.0 | 4813.19 |
| Assay(HPLC) | 95.0~105.0%(on anhydrous and salt-free substance basis) | 100.10% |
Feature D Pantethine is a more stable and active form of pantothenic acid (vitamin B5). It is also a precursor of coenzyme A (CoA) in…
Feature Tannic Acid powder is an ester substance formed by the combination of five hydroxyl groups of glucose and galloyl galloyl. The molecular weight is…
Feature To help diverse consumers meet their nutritional needs, our company is developing a variety of products and striving to establish a new brand in…
