Retatrutide is a multi-receptor peptide agonist that activates GLP-1 receptors, GIP receptors, and glucagon receptors. It has beneficial effects on metabolism, appetite regulation, and energy expenditure.
It is an experimental weight loss and antidiabetic drug ingredient. It is more effective than tirzepatide.
| Feature | Retatrutide |
|---|---|
| Type | Triple agonist (GLP-1/GIP/glucagon) |
| Purpose | Obesity, Type 2 diabetes |
| Status | Phase 3 trials |
| Weight Loss Effect | ~24% in trials (at high dose) |
Product name | Retatrutide |
| CAS NO | 2381089-83-2 |
| Sequence | Tyr- {Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile- { α-Me-Leu}-Leu-Asp-Lys- {diacid-C20-gamma-Glu-(AEEA)-Lys}- Ala-Gln- {Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro -Pro-Ser-NH2 |
| Molecular Formula | C221H342N46O68 |
| Molecular Weight | 4731.33 |
| Store at | Keep in dark and cool dry place |
| Items | Standards | Results |
| Appearance | White to off-white powder | Complies |
| Identity by MS | Theoretical MW:4731.33 | Complies |
| Purity (HPLC) | Not less than 98.0% | 99.16% |
| Sodium salt | Not more than 5.0% | 0.61% |
| Water Content (K.F) | Not more than 7.0% | 3.58% |
| Peptide Content | Not less than 85.0% | Complies |
| Conclusion | Conforms to standard | Complies |
GLP-1 reduces appetite, slows gastric emptying, and promotes insulin secretion.
GIP may reduce food intake and promote insulin secretion.
Glucagon increases energy expenditure.
Therefore, Retatrutide can provide excellent weight loss and metabolic control effects.
The ingredient is in clinical trials and has shown efficacy in both obesity and type 2 diabetes.
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