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Pentagastrin – Gastric Acid Secretion Stimulant

  • Pentagastrin
  • CAS number: 5534-95-2
  • Molecular weight: 767.9 g/mol
  • Molecular formula: C37H49N7O9S
  • Specifications: 98%
  • Test method:HPLC
  • Solubility: Soluble in dimethylformamide (DMF) and dilute ammonia; slightly soluble in alcohol

    【Product Overview】 We are a dedicated global supplier of Pentagastrin, a synthetic polypeptide comprising the C-terminal tetrapeptide amide of natural gastrin. It acts as a potent and specific physiological stimulant of gastric acid, pepsin, and intrinsic factor secretion. As the preferred alternative to natural gastrin or histamine, Pentagastrin is the critical active pharmaceutical ingredient (API) used in the Pentagastrin Stimulation Test for diagnosing achlorhydria, Zollinger-Ellison syndrome, and atrophic gastritis.

    【Key Advantages】

    Diagnostic Precision: Pentagastrin mimics the bioactivity of natural gastrin but with a more predictable and dose-dependent response. It is the industry benchmark for evaluating maximal acid output (MAO).

    Dual Application: Beyond gastric function, Pentagastrin is also widely researched as a provocation agent to stimulate the release of Calcitonin in the diagnosis of Medullary Thyroid Carcinoma (MTC), making it a versatile tool for endocrine diagnostics.

    Safety Profile: As a synthetic peptide, it avoids the severe side effects often associated with older histamine-based stimulation tests, offering a safer profile for clinical research subjects.

    High Purity Standard: We guarantee ≥99.0% purity (HPLC). Our synthesis ensures the integrity of the crucial C-terminal sequence (Trp-Met-Asp-Phe-NH2), which is responsible for the peptide's biological activity.

    【Logistics & Service】

    Temperature Control: We ship using validated thermal packaging to ensure the product maintains its chemical stability during transit.

    Global Compliance: We are experienced in shipping diagnostic APIs. We provide full HS Code support (typically 2937.19 or 2937.90) and necessary non-clinical declarations to facilitate smooth customs clearance to the US, EU, and Asia.

    Analytical Support: Comprehensive COA, including NMR, Mass Spectra, and HPLC purity reports, is provided to support your incoming quality control (IQC).

    Regulatory Disclaimer: This product is supplied as a Chemical Reference Standard or API Intermediate for laboratory research (R&D) and further manufacturing use only. It is NOT intended for direct human therapeutic use, clinical injection, or patient administration without regulatory approval.

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