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Nonapeptide-1 (Ref: Melanostatin DM) – Hyperpigmentation Antagonist

  • Nonapeptide-1
  • CAS number: 123689-72-5
  • Molecular weight: 1206.5 g/mol
  • Molecular formula: C61H87N15O9S
  • Specifications: 98%
  • Test method:HPLC
  • Solubility: Soluble in water

    【Product Overview】

    We are a premier global supplier of the active peptide for Melanostatin DM. This high-performance biomimetic peptide (Nonapeptide-1) acts as a specific antagonist to the α-Melanocyte Stimulating Hormone (α-MSH). By competitively blocking the receptors on melanocytes, it prevents the activation of Tyrosinase, effectively halting melanin synthesis before it begins. It is the preferred choice for formulators seeking a safe, reversible, and highly specific skin brightening agent.

    【Key Advantages】

    Specific MSH Antagonism: Unlike broad-spectrum inhibitors, this peptide specifically targets the MC1-R receptor. It locks the receptor, preventing the MSH hormone from triggering the pigmentation cascade. This "lock and key" mechanism ensures high efficacy with zero cytotoxicity.

    Ideal for Dextran Delivery: This peptide is chemically optimized to work synergistically with Dextran delivery systems (often found in the branded "DM" version). This compatibility ensures improved stability and sustained release in hydrogel or serum formulations.

    Reverses Tanning: It is particularly effective at inhibiting Facultative Pigmentation (darkening caused by UV exposure/tanning). It helps the skin recover its natural tone faster after sun exposure.

    High Safety Profile: It does not interfere with the cell's normal functions or viability. It is suitable for long-term use in daily brightening creams and spot correctors without the risk of irritation common with acid-based whiteners.

    【Logistics & Service】

    Cosmetic Grade Quality: Manufactured under strict cGMP guidelines for cosmetic ingredients.

    Global Export: We provide full regulatory support, including HS Codes (2937.19) and COA/MSDS.

    Formulation Note: Heat stable. Compatible with most thickeners and emulsifiers. Best added in the final phase of formulation (below 40°C).

    Regulatory Disclaimer: This product is supplied as a Cosmetic Raw Material for further manufacturing and R&D use only. It is intended for topical application and is not for injection.

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