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Melittin

  • CAS Number : 20449-79-0
  • Specification: ≥98.0%
  • Appearance: Light Yellow Powder
  • Molecular Formula: C37H42F2N8O4
  • Molecular Weight : 2846.46
  • Certificate:Halal/Kosher/ISO9001/GMO free

    Feature

    Melittin is the main active ingredient in bee venom, accounting for about 40-60% of its dry weight. It is a short-chain amphipathic peptide composed of 26 amino acids, and its secondary structure is an alpha helical structure.
    This substance has good biological activity and has hydrophobic and hydrophilic regions, which enable it to enter and destroy cell membranes.
    Melittin is the cause of pain and inflammation caused by bee stings. In addition, it also has some potential pharmacological properties.

    Specification-COA

    ItemsSpecificationsResults
    ProteinNot less than 98%98.7%
    Loss on dryingNot more than 3%2.52%
    Water insoluble substancesNot more than 4%conform
    total ashNot more than 2%1.27%
    Activity of phospholipase A2 IU/mgNot less than 30%34%
    Haemolysis Not more than 20mg/ml18.9mg/ml
    PH4.5-6.55.3
    Melittin Not less than 40%54.8%
    Conclusion: in conformity with the enterprise standard

    Function and Application

    1. Anti-inflammatory
      Meet venom can inhibit phospholipase A2 and reduce inflammation by regulating pathways such as NF-κB.
    2. Antibacterial
      Meet venom peptide can destroy microbial membranes and inhibit the growth and reproduction of more than 20 types of Gram-positive and Gram-negative bacteria and fungi.
    3. Antiviral
      Enhance the antibacterial efficacy of sulfonamides and penicillins, and reduce the infectivity of viruses.

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