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Hydrocortisone Powder

  • Ref standard:Ph.Eur.9/USP43
  • CAS No.:50-23-7
  • Molecular Formula:C21H30O5
  • Molecular Weight:362.47
  • Appearance:White crystalline powder
  • GMP standard production lines
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                            Feature

                            Hydrocortisone is the main hormone of the adrenal cortex. It is a short-acting glucocorticoid and also has a weak mineralocorticoid effect.
                            It is involved in many physiological processes of the human body, including anti-inflammatory, anti-allergic, anti-shock, and immune regulation.
                            It has short-acting characteristics, direct activity and multiple dosage forms, and plays an important role in the field of emergency and critical care and skin disease treatment.

                            Specification-COA

                            ItemsStandardResults
                            DescriptionWhite to practically white, odorless,crystalline powder.white crystalline powder
                            SolubilitySparingly soluble in acetone and in alcohol,slightly soluble in chloroform; very slightly soluble in water and in ether.complies
                            IdentificationA.IR  B.UV
                            Specific rotaion+150°-156°153.6°
                            Loss on drying≤1.0%0.03%
                            Residual ignition≤0.5%0.03%
                            Total impurities≤2.0%0.59%
                            Any max individual impurity≤0.5%0.10%
                            Particle size90%≤20um
                            Residual SolventMethanol ≤3000ppm97 ppm
                            Dichloromethane ≤600ppm62 ppm
                            Acetone≤5000ppmND
                            Tetrahydrofuran≤720ppmND
                            Assay(HPLC)97%-102%100.10%
                            Conclusion The test product complies with the requirements of USP43.

                            Function and Application

                            Hydrocortisone powder is an active pharmaceutical ingredient (API) and is commonly used in pharmaceutical formulations.

                            1. Production of topical creams/ointments to improve skin conditions like eczema, dermatitis, and rash.
                            2. Oral tablets for the treatment of adrenal insufficiency and autoimmune diseases.
                            FormUsage
                            Topical (cream)For skin inflammation
                            Oral tabletFor systemic inflammation
                            InjectionFor emergencies or adrenal crisis
                            Rectal (suppository/foam)For hemorrhoids, proctitis

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