Febrifugine is a natural alkaloid compound isolated from Dichroa febrifuga, traditionally used to treat malaria and fever. It is a synthetic derivative with low toxicity and can also be used in veterinary medicine. The crude extract of febrifugine has low toxicity and is safe for clinical use.
A halogenated derivative of febrifugine, halofugone has better antimalarial activity and fewer side effects. Therefore, halofugone is approved by the FDA for use as an antiparasitic drug for animals.
| Property | Description |
|---|---|
| Source | Dichroa febrifuga (Hydrangea family plant) |
| Structure | Quinolizidine alkaloid |
| Activity | Potent antimalarial and antiparasitic effects |
| Derivatives | Halofuginone (a synthetic derivative used in research and medicine) |
| Item | Standard | Test Results | |
| Identification | A.H-NMR:Comply with the structure | Complies | |
| B.LC-MS:Comply with the structure | Complies | ||
| C.The IR spectrum of sample should be identical with that of reference standard; | Complies | ||
| D.HPLC-ESI-MS The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. | Complies | ||
| Crystallinity | meets the requirements. | Complies | |
| Loss on drying | ≤2.0% | 0.19% | |
| Heavy metals | ≤10 ppm <10ppm | ||
| Water | ≤1.0% | 0.1% | |
| Sulphated ash | ≤0.5%, determined on 1.0 g. | 0.009% | |
| Related substances | Unspecified impurities: for each impurity | ≤0.10% | <0.10% |
| Total Impurity | ≤0.5% | 0.18% | |
| Purity | ≥99.0% | 99.7% | |
| Assay | 99.0%~101.0% (anhydrous substance). | 99.8% | |
| Microbiological Analysis | |||
| Total plate count | ≤1000cfu/g | Complies | |
| Yeast and Moulds | ≤100cfu/g | Complies | |
| E. Coli. | Absent | Negative | |
| Salmonella | Absent | Negative | |
| S.aureus | Absent | Negative | |
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