Febrifugine is a natural alkaloid compound isolated from Dichroa febrifuga, traditionally used to treat malaria and fever. It is a synthetic derivative with low toxicity and can also be used in veterinary medicine. The crude extract of febrifugine has low toxicity and is safe for clinical use.
A halogenated derivative of febrifugine, halofugone has better antimalarial activity and fewer side effects. Therefore, halofugone is approved by the FDA for use as an antiparasitic drug for animals.
| Property | Description |
|---|---|
| Source | Dichroa febrifuga (Hydrangea family plant) |
| Structure | Quinolizidine alkaloid |
| Activity | Potent antimalarial and antiparasitic effects |
| Derivatives | Halofuginone (a synthetic derivative used in research and medicine) |
| Item | Standard | Test Results | |
| Identification | A.H-NMR:Comply with the structure | Complies | |
| B.LC-MS:Comply with the structure | Complies | ||
| C.The IR spectrum of sample should be identical with that of reference standard; | Complies | ||
| D.HPLC-ESI-MS The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. | Complies | ||
| Crystallinity | meets the requirements. | Complies | |
| Loss on drying | ≤2.0% | 0.19% | |
| Heavy metals | ≤10 ppm <10ppm | ||
| Water | ≤1.0% | 0.1% | |
| Sulphated ash | ≤0.5%, determined on 1.0 g. | 0.009% | |
| Related substances | Unspecified impurities: for each impurity | ≤0.10% | <0.10% |
| Total Impurity | ≤0.5% | 0.18% | |
| Purity | ≥99.0% | 99.7% | |
| Assay | 99.0%~101.0% (anhydrous substance). | 99.8% | |
| Microbiological Analysis | |||
| Total plate count | ≤1000cfu/g | Complies | |
| Yeast and Moulds | ≤100cfu/g | Complies | |
| E. Coli. | Absent | Negative | |
| Salmonella | Absent | Negative | |
| S.aureus | Absent | Negative | |
Feature Licorice is a compound that is both a medicine and food. Licorice extract powder is generally extracted from the dried roots and rhizomes of…
Feature Tea polyphenols (Camellia sinensis polyphenols) is the general term for phenolic compounds in tea. Catechins are the main components of tea polyphenols, accounting for…
Feature Benzophenone-4 BP-4 is a UV absorber and light stabilizer. The UV photolysis of benzophenone groups will produce highly reactive triplet intermediates. It can absorb…
