Artemisinin is extracted from the leaves of Artemisia annua and is a sesquiterpene lactone compound containing a peroxide bridge structure. It is a natural compound with antimalarial properties, with the advantages of rapid onset and low toxicity.
Currently, the industrial methods for obtaining artemisinin are mainly extraction, separation, and purification.
Artemisinin powder is almost insoluble in water, but soluble in organic solvents such as ethanol and ether.
| Items | Specifications | Results |
| Solubility | It is easily soluble in acetone, ethyl acetate, chloroform, soluble in methanol, ethanol, ethanol, ether and petroleum ether, almost insoluble in water, and easily soluble in glacial acetic acid. | Conforms |
| Appearance | Colorless needle-shaped crystals, bitter taste | Conforms |
| Melting point | 150-153℃ | 150.9-151.8℃ |
| Specific rotation | +75℃—78° | 76.9° |
| Identification | ||
| Color reaction 1 | The solution should appear red | Conforms |
| Color reaction 2 | The solution should be dark purple | Conforms |
| HPLC | The retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution. | Conforms |
| IR | he infrared absorption spectrum of this product should be consistent with that of the reference product (spectral set 220). | Conforms |
| Detection | ||
| Related substances (Thin layer chromatography) | If the test solution shows spots, the depth is the same as that of the control solution. | Conforms |
| Loss on drying | ≤0.5% | 0.15% |
| Ignition residue | ≤0.1% | 0.05% |
| Content (dry product) | 98.0%—102.0%（HPLC） | 99.30% |
| Other tests | ||
| Related substances (HPLC) | Total impurities≤5.0% | 2.26% |
| Single impurity≤3.0% | 1.99% | |
| Clarity | Should be less than level 1 | Conforms |
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