Adapalene, with a molecular formula of C28H28O3, is a white or off-white powder at room temperature and is insoluble in water or ethanol. In 2016, the U.S. Food and Drug Administration approved Adapalene as an over-the-counter acne drug that can help unclog pores and control oil. Compared with retinoic acid and isotretinoin, Adapalene has the advantages of less irritation and fewer side effects.
| Test Items | Standard | Test Results |
| Characteristics | White to off white powder | Complies |
| Identification | IR Complies | Complies |
| Solubility | Practically insoluble in water and ethanol,sparingly soluble in tetrahydrofuran | Complies |
| Solution of appearance | Solution clear Colour ≤BY6 | Complies |
| Heavy metals | ≤20ppm | Complies |
| Loss on drying | ≤0.5% | 0.09% |
| Sulphated ash | ≤0.1% | 0.07% |
| Related substances | Impurity A ≤0.3% Impurity D ≤0.2% Impurity C ≤0.15% Unknow impurity ≤0.1% Total impurities ≤0.5% | 0.03% ND ND 0.01% 0.04% |
| Residual solvent | Tetrahydrofuran ≤720ppm Acetic acid ≤5000ppm Methanol ≤3000ppm Dichloromethane ≤600ppm N,N-dimethyl formamide ≤880ppm | 490ppmNDNDNDND |
| Assay | 98.0~ 102.0% （On dried basis） | 99.8% |
| Conclusion | Complies with EP7.0 standard. | |
Adapalene is a dermatological drug. It is a substance similar to retinoic acid and has multiple pharmacological effects.
Feature Monk fruit is made into extracts through picking, cleaning, crushing, extraction and other processes, and then processed into powder, liquid, lozenges, etc. Monk fruit…
Feature Lemon balm is native to Europe and is used in traditional medicine to calm and protect the nervous system.Its leaves have a light lemon…
5 Deazaflavin is a modified flavin derivative that has different chemical and biological activities from conventional flavin.
