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Transdermal Peptide (TD-1) – Permeation Enhancer

  • Transdermal Peptide (TD-1)
  • CAS number: 918629-48-8
  • Molecular weight: 1063.17 g/mol
  • Molecular formula: C40H64N14O16S2
  • Specifications: 98%
  • Test method:HPLC
  • Solubility: Soluble in water and saline

    【Product Overview】

    We are a specialized global supplier of Transdermal Peptide (TD-1), a specific 11-amino acid cyclic peptide designed to revolutionize drug delivery. Unlike standard surfactants that damage the skin, TD-1 works via a specific biological mechanism (interacting with the Na+/K+-ATPase beta-subunit) to create transient, reversible openings in the epidermal barrier. We provide this cutting-edge excipient peptide to pharmaceutical formulators and cosmetic researchers aiming to deliver macromolecules (such as Insulin, Growth Hormone, and GLP-1) via topical application, eliminating the need for injections.

    【Key Advantages】

    Needle-Free Delivery Solution: TD-1 is the key to unlocking "Topical Bioavailability". Research demonstrates that co-administration of TD-1 allows large hydrophilic molecules (which normally cannot cross the skin) to reach systemic circulation via simple creams or gels.

    Specific Mechanism: It selectively binds to the C-terminus of the Na+/K+-ATPase β-subunit. This interaction modulates the skin's tight junctions transiently, enhancing permeability without causing the permanent skin damage or irritation associated with chemical enhancers (like DMSO).

    Versatile Carrier: It is widely researched as a co-factor for delivering a broad range of actives, including siRNA, Insulin, hGH, and Exenatide. This makes it an invaluable tool for developing "Patient-Friendly" formulations.

    High Purity & Safety: We guarantee ≥95.0% purity (HPLC). Our cyclic peptide structure (Cys2-Cys10 disulfide bridge) ensures stability in formulation bases, providing a consistent enhancement effect.

    【Logistics & Service】

    Formulation Support: TD-1 is a functional excipient. We can provide technical guidance on the optimal molar ratios (peptide-to-drug) required to achieve maximum skin penetration.

    Global Export: We are experienced in shipping functional peptides globally. We provide full HS Code support (typically 2937.19 or 3504.00) to facilitate fast customs clearance to the US, EU, and Asia.

    Analytical Data: Every batch is tested for sequence correctness (MS) and purity (HPLC) to ensure it meets the stringent requirements of transdermal delivery research.

    Regulatory Disclaimer: This product is supplied as a Chemical Reference Standard or Formulation Excipient for laboratory research (R&D) and further manufacturing use only. It is NOT intended for direct human therapeutic use, clinical application, or patient administration without regulatory approval.

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