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Naltrexone Powder

  • CAS:16590-41-3
  • Molecular formula: C20H23NO4
  • Molecular weight: 341.4
  • Appearance:white powder
  • Specification :99%
  • OEM ODM available

    Feature

    Naltrexone powder is a pure opioid receptor antagonist.
    Naltrexone hydrochloride is a long-acting API that can prevent opioid dependence and alcohol dependence. It reduces patients' craving for opioids and alcohol. It can significantly improve patients' treatment compliance and provide them with stable and continuous withdrawal support.

    EffectHow It WorksUsed For
    Blocks opioid effectsCompetes with opioids at receptor sitesPrevents opioid relapse
    Reduces alcohol pleasure & cravingInhibits endorphin feedbackAlcohol dependence
    Boosts natural endorphins (LDN)Temporary receptor blockadeAutoimmune, chronic pain (off-label)

    Specification-COA

    TestSpecificationResult
    DescriptionWhite to off white powderOff white powder
    SolubilitySoluble in methanoi, chloroform
    and methylene chloride.
    Meets the test.
    Identification
    a) Infrared Absorption Spectruma ) To be concordant with working standarda) Concordant with working standard
    b) Melting Pointb) 167° to 175°Cb) 169℃
    WaterNMT 6.00%5.18%
    Heavy MetalsNMT 20 ppmLess than 20 ppm
    Residue on ignitionNMT 0.10 %0.02%
    Related Compounds
    a) Impurity B (Noroxymorphone)a) Not more than 0.50%a) 0.16%
    b) Any other impurityb) Not more than 0.25%b) 0.18%
    c) Total impuritiesc) Not more than 1.50%c) 0.28%
    Assay by HPLC(Area normalization)NLT 98.00%99.55%
    Assay by Titration(On anhydrous basis)98.00% to 102.00%99.41%

    What exactly does naltrexone do?

    1. Blocking opioid receptors (μ, κ, δ).
      Naltrexone binds to opioid receptors in the brain, preventing opioids from binding to these receptors.
    2. Reducing cravings for alcohol.
      Alcohol indirectly stimulates the release of endorphins, which bind to opioid receptors, and naltrexone blocks these receptors. This reduces the desire to drink and reduces relapse rates.
    3. Regulating the immune system.
      Temporarily blocking opioid receptors helps regulate the immune system, reduce inflammation, and reduce pain.

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