Naltrexone powder is a pure opioid receptor antagonist.
Naltrexone hydrochloride is a long-acting API that can prevent opioid dependence and alcohol dependence. It reduces patients' craving for opioids and alcohol. It can significantly improve patients' treatment compliance and provide them with stable and continuous withdrawal support.
| Effect | How It Works | Used For |
| Blocks opioid effects | Competes with opioids at receptor sites | Prevents opioid relapse |
| Reduces alcohol pleasure & craving | Inhibits endorphin feedback | Alcohol dependence |
| Boosts natural endorphins (LDN) | Temporary receptor blockade | Autoimmune, chronic pain (off-label) |
| Test | Specification | Result |
| Description | White to off white powder | Off white powder |
| Solubility | Soluble in methanoi, chloroform and methylene chloride. | Meets the test. |
| Identification | ||
| a) Infrared Absorption Spectrum | a ) To be concordant with working standard | a) Concordant with working standard |
| b) Melting Point | b) 167° to 175°C | b) 169℃ |
| Water | NMT 6.00% | 5.18% |
| Heavy Metals | NMT 20 ppm | Less than 20 ppm |
| Residue on ignition | NMT 0.10 % | 0.02% |
| Related Compounds | ||
| a) Impurity B (Noroxymorphone) | a) Not more than 0.50% | a) 0.16% |
| b) Any other impurity | b) Not more than 0.25% | b) 0.18% |
| c) Total impurities | c) Not more than 1.50% | c) 0.28% |
| Assay by HPLC(Area normalization) | NLT 98.00% | 99.55% |
| Assay by Titration(On anhydrous basis) | 98.00% to 102.00% | 99.41% |
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