×

product

LL-37 (Human Cathelicidin) – Host Defense Peptide

  • LL-37
  • CAS number: 154947-66-7
  • Molecular weight: 4493.3 g/mol
  • Molecular formula: C205H340N60O53
  • Specifications: 98%
  • Test method:HPLC
  • Solubility: Soluble in water and saline

    【Product Overview】 We are a premier global supplier of LL-37, the synthetic equivalent of the sole human cathelicidin antimicrobial peptide found in neutrophils and epithelial cells. As a pivotal component of the innate immune system, LL-37 is one of the most extensively studied peptides in the world. We provide high-purity, research-grade LL-37 to pharmaceutical developers and academic laboratories investigating novel antibiotics, anti-biofilm strategies, and wound healing mechanisms.

    【Key Advantages】

    The Human Standard: Unlike bovine or porcine AMPs, LL-37 is human-specific. It is the absolute prerequisite control for any study involving human innate immunity, inflammation, or autoimmune skin conditions (like Rosacea and Psoriasis).

    Biofilm Eradication: LL-37 is renowned for its potent Anti-Biofilm activity. It effectively inhibits the formation of and degrades existing bacterial biofilms (e.g., Pseudomonas aeruginosa, Staphylococcus aureus), a capability that traditional antibiotics often lack.

    Immune Modulation: Beyond killing bacteria, it acts as a "chemotactic agent," signaling and recruiting immune cells (neutrophils, monocytes) to the site of infection and promoting angiogenesis for tissue repair.

    High Purity Assurance: We guarantee ≥95.0% purity (HPLC). Synthesizing this 37-amino acid peptide requires advanced purification techniques to remove truncated deletion sequences. Our process ensures a highly active, full-length peptide.

    【Technical Specifications】

    Chemical Name: LL-37; Human Cathelicidin Antimicrobial Peptide (CAMP)

    CAS Number: 154947-66-7

    Sequence: Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-NH2 (37 AA)

    Mechanism: Membrane Disruption (Toroidal Pore) / Biofilm Inhibition / Chemotaxis

    Molecular Formula: C205H340N60O53

    Molecular Weight: 4493.3 g/mol

    Appearance: White to off-white lyophilized powder

    Solubility: Soluble in water and saline.

    Storage: Store at -20°C. Stable for 12 months if kept dry and frozen.

    【Logistics & Service】

    Cold Chain Logistics: We utilize validated thermal packaging (VIP box + ice packs) to ensure the peptide structure remains stable during international transit.

    Global Export: We are experienced in shipping biological research reagents. We provide full HS Code support (typically 2937.19 or 3002.90) and non-infectious/non-clinical declarations to facilitate smooth customs clearance to the US, EU, and Asia.

    Custom Formats: Available in standard 1mg/5mg vials or bulk grams for large-scale antimicrobial screening.

    Regulatory Disclaimer: This product is supplied as a Chemical Reference Standard or API Intermediate for laboratory research (R&D) and further manufacturing use only. It is NOT intended for direct human therapeutic use, clinical injection, or patient administration without regulatory approval.

    Related Products

    View All