Feature

Aldehyde dehydrogenase-2 (ALDH2) is the most active aldehyde dehydrogenase.
ALDH converts acetaldehyde and other aliphatic aldehydes into their corresponding acids. ALDH2 gene polymorphism directly affects the concentration of ethanol and acetaldehyde in the body. After ethanol enters the human body, it is first dehydrogenated into acetaldehyde by ADH catalysis, and then dehydrogenated into acetic acid by ALDH catalysis.
Importantly, the concentration of acetaldehyde is determined by mitochondrial ALDH2, so the activity of this enzyme is particularly important. By testing the ALDH2 genotype, we can understand our own ability to metabolize alcohol.

Specification-COA

Function

As a mitochondrial isozyme, ALDH2 plays an important role in the metabolic process.
It plays a key role in the metabolism of endogenous and exogenous aldehydes and is closely related to the occurrence of cardiovascular diseases.
ALDH2 is an important metabolic enzyme of nitroglycerin. Nitroglycerin is a drug widely used in ischemic heart disease and congestive heart failure. It needs to be metabolized by ALDH2 in the body into pharmacologically active nitric oxide to exert its pharmacological effects.